Publications | fascionelab

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Hatton, N. E., Nabarro, J., Yates, N. D. J., Parkin, A., Wilson, L. G., Baumann, C. G., & Fascione, M. A. Mannose Presenting ‘Glyco-Colicins’ Convert the Bacterial Cell Surface into a Multivalent Adsorption Site for Adherent Bacteria. ChemRxiv, 2024, 10.26434/chemrxiv-2024-9p76x

Hollingsworth, K., Di Maio, A., Richards, S. J., Vendeville, J-B., Wheatley, D. E., Council, C. E., Keenan, T., Ledru, H., Chidwick, H., Huang, K., Parmeggiani, F., Marchesi, A., Chai, W., McBerney, R., Kaminski, T. P., Balmforth, M. R., Tamasanu, A., Charnock, S., Warriner, S. L., Webb, M. E., Fascione, M. A., Flitsch, S., Galan, M. C., Feizi, T., Gibson, M. I, Liu, Y., Turnbull, W. B. & Linclau, B. A ‘glyco-fluorine’ code revealing differential recognition by glycan binding partners. ChemRxiv, 2023, 10.26434/chemrxiv-2023-4hn6k

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Hutton, E., Scott., E., Robson, C. N., Signoret, N. Y. M. & Fascione, M. A. A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification. Front. Mol. Biosci., 2024, accepted

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Yang, Z., Arnoux, M., Hazard, D., Hughes, O. R., Nabarro, J., Whitwood, A. C., Fascione, M. A., Spicer, C. D., Compain, P. & Unsworth, W. P. Expanding the scope of the Successive Ring Expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams. Org. Biomol. Chem., 2024, 22, 2985-2991

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Warnes, M. E. & Fascione, M. A. Bimodal Glycosyl Donors as an Emerging Approach Towards a General Glycosylation Strategy. Chem. Eur. J., 2024, accepted

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Jumeaux, C., Spicer, C. D., Charchar, P., Howes, P. D., Holme, M. N., Ma, L., Rose, N. C., Nabarro, J., Fascione, M. A., Rashid, M. H., Yarovsky, I. & Stevens, M. M. Strain-Promoted Cycloadditions in Lipid Bilayers Triggered by Liposome Fusion. Angew. Chem. Int. Ed., 2024, 63, e202314786

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Walklett, A., Flack, E., Chidwick, H., Hatton, N., Keenan, T., Budhadev, D., Walton, J., Thomas, G. H., & Fascione, M. A. The Retaining Pse5Ac7Ac Pseudaminyltransferase KpsS1 Defines a Previously Unreported Glycosyltransferase Family (GT118). Angew. Chem. Int. Ed., 2024, 63 (15), e202318523

Highlighted as a Hot Article, and Martin highlighted in Angew Introducing...

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Tufail, A., Akkad, S., Hatton, N., Yates, N., Spears, R., Keenan, T., Parkin, A., Signoret, N. Y. M., & Fascione, M. A. Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal a-oxo aldehydes at acidic pH. RSC Adv., 2024,14, 3723-3729

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Keenan, T., Chidwick, H., Best, M., Flack, E., Yates, N., Hatton, N., Warnes, M. E., & Fascione, M. A. Co-factor prosthesis facilitates biosynthesis of azido-pseudaminic acid probes for use as glycosyltransferase reporters. Chem. Commun., 2024, 60, 1428-1431

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Yates, N., Miles, C., Spicer, C., Fascione, M. A., & Parkin, A. Crossing the Solubility Rubicon: 15-Crown-5 Facilitates the Preparation of Water-Soluble Sulfo-NHS Esters in Organic Solvents. Bioconjug. Chem., 2024, 35 (1), 22-27

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Keenan, T., Hatton, N., Porter, J., Vendeville, J-B., Wheatley, D., Ghirardello, M., Ahmadipour , S., Walton, J., Galan, M. C., Linclau, B., & Miller, G. J., & Fascione, M. A. Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library. Chem. Sci., 2023,14, 11638-11646

Highlighted as inside Back Cover article

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Yates, N. D. J., Hatton, N. E., Fascione, M. A., & Parkin, A. Site-Selective Aryl Diazonium Installation onto Protein Surfaces at Neutral pH using a Maleimide-Functionalized Triazabutadiene. ChemBioChem, 2023, 24 (16), e202300313

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Yates, N. D. J., Warnes, M. E., Breetveld, R., Spicer, C. D., Signoret, N., & Fascione, M. Preparation and Application of an Inexpensive α‐Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis. Org. Lett., 2023, 25 (12), 2001-2005

Highlighted as Front Cover article

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Barber, L. J., Yates, N. D. J., Fascione, M. A., Parkin, A., Hemsworth, G. R., Genever, P. G., & Spicer, C. D. Selectivity and stability of N-terminal targeting protein modification chemistries. RSC Chem. Biol., 2023, 4, 56-64

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Anna , A., Calle, B., Rizou, T., Lowery, S., Bridgeman, V., Mahoney, K., Marchesi, A., Bineva-Todd, G., Flynn, H., Li, Z., Yilmaz Tastan, O., Roustan, C., Soro-Barrio, P., Rafiee, M-R., Garza-Garcia, A., Antonopoulos, A., Wood, T., Keenan, T., Both, P., Huang, K., Parmeggiani, F., Snijders, A. P., Skehel, M., Kjaer, S., Fascione, M. A., Bertozzi, C. R., Haslam, S. M., Flitsch, S., Malaker, S. A., Malanchi, I., & Schumann, B. Cell-specific bioorthogonal tagging of glycoproteins. Nat. Commun., 2022, 13, Article no. 6237

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Yates, N., Akkad, S., Noble, A., Keenan, T., Hatton, N., Signoret, N. Y. M., & Fascione, M. A. Catalyst-free site-selective cross-aldol bioconjugations. Green Chem., 2022 , 24, 8046-8053

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Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N., & Fascione, M. A. A tale of two bioconjugations: pH controlled divergent reactivity of protein a-oxo aldehydes in competing a-oxo-Mannich and catalyst-free aldol ligations. ACS Chem. Biol., 2021, 16 (11), 2387-2400

Published as part of the ACS Young Investigators virtual special issue

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Chidwick, H., Flack, E., Keenan, T., Walton, J., Thomas, G. H., & Fascione, M. A. Reconstitution and optimisation of the biosynthesis of bacterial sugar pseudaminic acid (Pse5Ac7Ac) enables preparative enzymatic synthesis of CMP-Pse5Ac7Ac. Sci. Rep., 2021, 11, Article no. 4756

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Richards, S-J., Keenan, T., Vendeville, J-B., Wheatley, D. E., Chidwick, H., Budhadev, D., Council, C. E., Webster, C. S., Ledru, H., Baker, A. N., Walker, M., Galan, M. C., Linclau, B., Fascione, M. A., & Gibson, M. I. Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands. Chem. Sci., 2021,12, 905-910

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Hatton, N., Baumann, C. G., & Fascione, M. A. Developments in mannose-based treatments for Uropathogenic Escherichia coli induced urinary tract infections. ChemBioChem, 2021, 22 (4), 613-629

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Flack, E., Chidwick, H., Guchhait, G., Keenan, T., Budhadev, D., Huang, K., Both, P., Mas Pons, J., Ledru, H., Rui, S., Stafford, G., Shaw, J., Galan, M. C., Flitsch, S. L., Thomas, G. H., & Fascione, M. A. Biocatalytic Transfer of Pseudaminic Acid (Pse5Ac7Ac) Using Promiscuous Sialyltransferases in a Chemoenzymatic Approach to Pse5Ac7Ac Containing Glycosides. ACS Catal., 2020, 10 (17), 9986-9993

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Keenan, T., Parmeggiani, F., Malassis, J., Fontenelle, C., Vendeville, J-B., Offen, W. A., Both, P., Huang, K., Marchesi, A., Heyam, A. P., Young, C., Charnock, S. J., Davies, G. J., Linclau, B., Flitsch, S. L., & Fascione, M. A. Profiling substrate promiscuity of wild-type sugar kinases for multifluorinated monosaccharides. Cell Chem. Biol., 2020, 27 (9), 1199-1206

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Brabham, R., Keenan, T., Husken, A., Bilsborrow, J., McBerney, R., Kumar, V., Turnbull, W. B., & Fascione, M. A. Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation. Org. Biomol. Chem., 2020, 18, 4000-4003

Highlighed as a part of the themed collections: Editor's choice; Chemical Biology in OBC; Methodology development for protein modifications

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Valverde, P., Vendeville, J-B., Hollingsworth, K., Mattey, A. P., Keenan, T., Chidwick, H., Ledru, H., Huonnic, K., Light, M. E., Turner, N., Jimenez Barbero, J., Galan, M. C., Fascione, M. A., Flitsch, S., Turnbull, W. B., & Linclau, B. Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates. Chem. Commun., 2020, 56, 6408-6411

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Flack, E., Chidwick, H., Best, M., Thomas, G. H., & Fascione, M. A. Synthetic Approaches for Accessing Pseudaminic Acid (Pse) Bacterial Glycans. ChemBioChem, 2020 , 21, 1-12.

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Chidwick, H., & Fascione, M. A. Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac). Org. Biomol. Chem., 2020, 18, 799-809

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Yates, N., Dowsett, M., Bentley, P., Dickenson-Fogg, J., Pratt, A., Blanford, C., Fascione, M. A., & Parkin, A. Aldehyde-mediated protein-to-surface tethering via controlled diazonium electrode functionalization using protected hydroxylamines. Langmuir, 2020, 36 (20), 5654–5664

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Simpson, J. P., Fascione, M., Bergström, E., Wilson, J., Collins, M. J., Penkman, K. E. H., & Thomas-Oates, J. Ionisation bias undermines the use of matrix-assisted laser desorption/ionisation for estimating peptide deamidation: Synthetic peptide studies demonstrate electrospray ionisation gives more reliable response ratios. Rapid Commun. Mass Spectrom., 2019, 33 (12), 1049-1057

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Yates, N. D. J., Brabham, R. L., Spears, R. J., Keenan, T., Helliwell, P. A., Pugh, D. S., Parkin, A., Hurst, G. A., & Fascione, M. A. Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus. J. Chem. Educ., 2019, 96 (6), 1245-1249

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Keenan, T., Mills, R., Pocock, E., Budhadev, D., Parmeggiani, F., Flitsch, S. L., & Fascione, M. A. The characterisation of a galactokinase from Streptomyces coelicolor. Carbohydr. Res., 2019, 472, 132-137

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Budhadev, D., Saxby, K., Walton, J., Davies, G. J., Tyler, P., Schworer, R., & Fascione, M. A. Using Automated Glycan Assembly (AGA) for the Practical Synthesis of Heparan Sulfate Oligosaccharide Precursors. Org. Biomol. Chem., 2019, 7, 1817-1821

Highlighed as part of the themed collection: New Talent

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Spears, R. J., Brabham, R. L., Budhadev, D., Keenan, T., McKenna, S. E., Walton, J., Brannigan, J. A., Brzozowski, A. M., Wilkinson, A. J., Plevin, M. J., & Fascione, M. A. Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations. Chem. Sci., 2018, 9, 5585-5593

Highlighed as a "Hot article" and part of the themed collection: 2021 Nobel Prize in Chemistry – Asymmetric Organocatalysis

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Yates, N. D. J., Fascione, M. A., & Parkin, A. Methodologies for “Wiring” Redox Proteins/Enzymes to Electrode Surfaces. Chem. Eur. J., 2018, 24, 1-20

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Brabham, R. L., Spears, R. J., Walton, J., Tyagi, S., Lemke, E., & Fascione, M. A. Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification. Chem.Commun., 2018, 54, 1501-1504

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Budhadev, D., Schworer, R., & Fascione, M. A. Modern Methods for the Synthesis of Carbohydrates. In Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, 2018, pp. 234-269. The Royal Society of Chemistry.

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Mahon, C. S., J. McGurk, C., M. D. Watson, S., Fascione, M. A., Sakonsinsiri, C., Turnbull, W. B., & Fulton, D. A. Molecular-recognition mediated transformation of single-chain polymer nanoparticles into crosslinked polymer films. Angew. Chem. Int. Ed., 2017, 56 (42), 12913-12918

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Brabham, R. L., & Fascione, M. A. Pyrrolysine Amber Stop Codon Suppression: Development and Applications. ChemBioChem, 2017, 18 (20), 1937-1983

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Brabham, R. L., & Fascione, M. A. Chiral auxiliaries in stereoselective glycosylation reactions. In C. Bennett (Ed.), Selective Glycosylations: Synthetic Methods and Catalysts, 2017, pp. 97-112. Wiley-Blackwell.

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Spears, R. J., & Fascione, M. A. Site-selective incorporation and ligation of protein aldehydes. Org. Biomol. Chem., 2016, 14 (32), 7622-7638

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Guy, Y., Sakonsinsiri, C., Nehlmeier, I., Fascione, M. A., Zhang, H., Wang, W., Pohlmann, S., Turnbull, W. B., & Zhou, D. Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein–Ligand Interactions. Angew. Chem. Int. Ed., 2016, 55 (15), 4738-4742

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Fascione, M. A., Brabham, R., & Turnbull, W. B. Mechanistic Investigations into the Application of Sulfoxides in Carbohydrate Synthesis. Chem. Eur. J., 2016, 22 (12), 3916-3928

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Mahon, C. S., Fascione, M. A., Sakonsinsiri, C., McAllister, T. E., Turnbull, W. B., & Fulton, D. A. Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins. Org. Biomol. Chem., 2015, 13 (9), 2756-2761

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Branson, T. R., McAllister, T. E., Garcia-Hartjes, J., Fascione, M. A., Ross, J. F., Warriner, S. L., Wennekes, T., Zuilhof, H., & Turnbull, B. A protein-based pentavalent inhibitor of the Cholera toxin B-subunit. Angew. Chem. Int. Ed., 2014, 53 (32), 8323-8327

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Williamson, D. J., Fascione, M. A., Webb, M. E., & Turnbull, W. B. Efficient N-terminal labeling of proteins by use of sortase. Angew. Chem. Int. Ed., 2012, 51 (37), 9377-9380

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Fascione, M. A., Adshead, S. J., Mandal, P. K., Kilner, C. A., Leach, A. G., & Turnbull, W. B. Mechanistic studies on a sulfoxide transfer reaction mediated by diphenyl sulfoxide/triflic anhydride. Chem. Eur. J., 2012, 18 (10), 2987-2997

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Fascione, M. A., Webb, N. J., Kilner, C. A., Warriner, S. L., & Turnbull, W. B. Stereoselective glycosylations using oxathiane spiroketal glycosyl donors. Carbohydr. Res., 2012, 348, 6-13

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Fascione, M. A., Kilner, C. A., Leach, A. G., & Turnbull, W. B. Do glycosyl sulfonium ions engage in neighbouring-group participation? A Study of oxathiane glycosyl donors and the basis for their stereoselectivity. Chem. Eur. J., 2012, 18 (1), 321-333

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Fascione, M. A., & Turnbull, W. B. Benzyne arylation of oxathiane glycosyl donors. Beilstein J. Org. Chem., 2010, 6, No. 19

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Stalford, S. A., Fascione, M. A., Sasindran, S. J., Dhandayuthapani, S., Chatterjee, D. & Turnbull, W. B. A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A. Chem. Commun., 2009, 1, 110-112

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Fascione, M. A., Adshead, S. J., Stalford, S. A., Kilner, C. A., Leach, A. G., & Turnbull, W. B. Stereoselective glycosylation using oxathiane glycosyl donors. Chem. Commun., 2009, 39, 5841-5843

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Turnbull, W. B., Fascione, M. A., & Stalford, S. A. Product Class 14: glycosyl sulfur, selenium and tellurium compounds. In Science of Synthesis, 2007, Vol. 29, 923-969. Georg Thieme Verlag.

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