Publications | fascionelab

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Karthika, A., Murray, M., Palop, G., Keane, L-A., Yates, N. D. J., Spicer, C. D., Parkin, A., Fascione, M. A. & Myers, E. Cysteine thioaldehydes: photolytic generation, reactivity and biological implications. ChemRxiv, 2025, 10.26434/chemrxiv-2025-zc9xb

Duxfield, A., Garnham, R., Hutton, E., Dowle, A., Wills, J., Luzzi, S., Nelson, R., Lishman-Walker, E., Magee, R., Buskin, A., Hepburn, A., C., Tekoglu, E., Maloney-Friar, K., Frame, F., Maitland, M., Hedley, A., Henderson, H., McCullough, B., Gowardhan, B., Sahadevan, K., McCracken, S., Gaughan, L., Heer, R., Robson, C. N., Coffey, K., Lack, N., Signoret, N., Fascione, M. A. & Scott. E. The androgen receptor and MYC synergise to modulate the synthesis of siglec-7 ligands in prostate cancer. BioRxiv, 2025, 10.1101/2025.10.15.682547

Nabarro, J., Hatton, N. E., Pushkin, D. O., Fascione, M. A. & Baumann, C. G. Persistent LPS insertion, spatial segregation and vesicle biogenesis drive growth-independent adaptation of the Escherichia coli outer membrane. BioRxiv, 2025, 10.1101/2025.10.09.681453

69

Anderson, O. H., Johnson, J. M., Flack, E. K. P., Fascione, M. A., Chong, J. P. J. & Thomas, G. H. Flagellar glycosylation with pseudaminic acids is widespread in the genus Clostridium. BMC Microbiol., 2026, accepted

68

Schwabe, B. T., Angstman, I. M., Palop, G., Vollheyde, K., Ingold, Z., Li, J., Stankevich, K. S., Spicer, C. D., Fascione, M. A., Grogan, G., Geu-Flores, F., & Lichman, B. R. Nicotine biosynthesis completed by cryptic activating glucosylation. Nat. Commun., accepted
BioRxiv, 2025, 10.64898/2025.12.04.692101

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Nabarro, J., Lehman, R. M., Lenton, S., Mantion, L., Spears, R. J., Coles, M. C., Pushkin, D. O., Fascione, M. A. & Baumann, C. G. Lipopolysaccharide lateral mobility in the Gram-negative bacterial outer membrane is confined and governed by interactions within the conserved Lipid A anchor. EMBO J., 2026, https://doi.org/10.1038/s44318-026-00711-5
BioRxiv, 2025, 10.1101/2025.03.10.642448

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66

Hughes, O, Tufail, A., Hutton, E., Nabarro, J., Howarth, R., Yates, N. D., Whitwood, A., Robson, C., Signoret, N., Fascione, M. A., Spicer, C. D. & Unsworth, W. P. N-terminal protein-macrocyles enabled by conjugate addition/ring expansion cascade reactions. Chem. Sci., 2026,17, 3320-3328
ChemRxiv, 2025, 10.26434/chemrxiv-2025-06817

65

Warnes, M. E. & Fascione, M. A. Discerning structural influences on stereoselectivity and kinetics in glycosylations with oxathiane donors. Eur. J. Org. Chem., 2026, e202500641

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64

Raynal, L., Nabarro, J., Miller, L., Dowle, A., Moul, S., Johnson, S., Fascione, M. A. & Spicer, C. Site-selective protein modification via peptide-directed proximity catalysis. ACS Omega, 2025, 10 (51), 62787-62792
ChemRxiv, 2024, 10.26434/chemrxiv-2024-qskp0

63

Jeffries, J., Walklett, A. J., Hatton, N. E., Kowalski, B., Keenan, T., Munjoma, L., Haigh, R., Bayliss, C. D., Thomas, G. H. & Fascione, M. A. Rational engineering of a pseudaminic acid synthase enzyme enables access to a 3-fluoro sugar with motility inhibition in bacterial pathogens. Angew. Chem. Int. Ed., 2025, 64 (50), e202515851
ChemRxiv, 2025, 10.26434/chemrxiv-2025-z95rr-v2

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Tufail, A, Warnes, M. E., Signoret, N. & Fascione, M. A. Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity pull-down using cross-aldol bioconjugations. RSC Chem. Biol., 2025, 6, 1772-1778
ChemRxiv, 2025, 10.26434/chemrxiv-2025-d64r5

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Welsh, L. R. J., Avrova, A. O., Besser, K., Kirkbride, T., Machado, C. B., Hatton, N. E., Gomez, L., Fascione, M. A, Cartwright, J., Boevink, P. C., Denby, K., Cannella, D., McQueen-Mason, S., Whisson, S. C. & Sabbadin, F. Oomycetes manipulate plant innate immunity through galacturonide oxidases. Nat. Commun., 2025, 16, Article number: 9093

60

Hutton, E., Uno, Y., Robson, C., Fascione, M. A. & Signoret, N. A general and accessible approach to enrichment and characterisation of natural anti-Neu5Gc antibodies from human samples. RSC Chem. Biol., 2025, 6, 1135-1147

59

Dolan, J., Keenan, T. K., Benckendorrf, C., Ni Cheallaigh, A., Fascione, M. A. & Miller, G. J. 3’-O-β-Glycosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase. RSC Chem. Biol., 2025, 6, 845-850

58

Leslie, K., Jolliffe, K., Müllner, TM., New, E., Fascione, M. A., Turnbull, W. B., Firman, V-P. & Mahon, C.
A glycopolymer sensor array that differentiates lectins and bacteria. Biomacromolecules, 2024, 25 (11), 7466-7474

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Tufail, A., Akkad, S., Noble, A. R., Fascione, M. A. & Signoret, N. New insight into a simple high-yielding method for the production of fully folded and functional recombinant human CCL5. Sci. Rep., 2024, 14, Article number: 24188

56

Hewson, A. R., Lloyd-Laney, H. O., Keenan, T. K., Richards, S-J., Gibson, M. I., Linclau, B., Signoret, N. S., Fascione, M. A. & Parkin, A. P. Harnessing glycofluoroforms for impedimetric biosensing. Chem. Sci, 2024, 15, 16086-16095

55

Keenan, T., Cowan, A. R., Flack, E. K. P., Hatton, N. E., Walklett, A. J., Thomas, G. H., Hemsworth, G. R. & Fascione, M. A. Structural dissection of the CMP-pseudaminic acid synthetase (PseF). Structure, 2024, 32, 1-11

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Hatton, N. E., Wilson, L. G., Baumann, C. G. & Fascione, M. A. Synthesis of Colicin Ia Neoglycoproteins: Tools Towards Glyco-Engineering of Bacterial Cell Surfaces. RSC Adv., 2024,14, 29106 - 29112

53

Hollingsworth, K., Di Maio, A., Richards, S. J., Vendeville, J-B., Wheatley, D. E., Council, C. E., Keenan, T., Ledru, H., Chidwick, H., Huang, K., Parmeggiani, F., Marchesi, A., Chai, W., McBerney, R., Kaminski, T. P., Balmforth, M. R., Tamasanu, A., Charnock, S., Warriner, S. L., Webb, M. E., Fascione, M. A., Flitsch, S., Galan, M. C., Feizi, T., Gibson, M. I, Liu, Y., Turnbull, W. B. & Linclau, B. Synthesis and screening of a library of Lewis deoxyfluoro-analogues reveals differential recognition by glycan-binding partners. Nat. Commun., 2024, 15, article number: 7925
Preprint: ChemRxiv, 2023, 10.26434/chemrxiv-2023-4hn6k

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Noble, A. R., Akkad, S., Yates, N. D. J., Jeffries, J. M., Signoret, N, & Fascione, M. A. Towards a ‘clicked’ PSMA Targeting Gene Delivery Bioconjugate-Polyplex for Prostate Cancer. RSC Adv., 2024, 14, 23796-23801

51

Porter, J., Noble, A. R., Signoret, N., Fascione, M. A. & Miller, G. J., Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug. ACS Omega, 2024, 9 (29), 31703-31713

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Hatton, N. E., Nabarro, J., Yates, N. D. J., Parkin, A., Wilson, L. G., Baumann, C. G., & Fascione, M. A. Mannose Presenting "Glyco-Colicins" Convert the Bacterial Cell Surface into a Multivalent Adsorption Site for Adherent Bacteria. JACS Au, 2024, 4 (6), 2122-2129

49

Hutton, E., Scott., E., Robson, C. N., Signoret, N. Y. M. & Fascione, M. A. A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification. Front. Mol. Biosci., 2024, 11, 1390711

48

Yang, Z., Arnoux, M., Hazard, D., Hughes, O. R., Nabarro, J., Whitwood, A. C., Fascione, M. A., Spicer, C. D., Compain, P. & Unsworth, W. P. Expanding the scope of the Successive Ring Expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams. Org. Biomol. Chem., 2024, 22, 2985-2991

47

Warnes, M. E. & Fascione, M. A. Bimodal Glycosyl Donors as an Emerging Approach Towards a General Glycosylation Strategy. Chem. Eur. J., 2024, 30 (29), e202400399

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46

Jumeaux, C., Spicer, C. D., Charchar, P., Howes, P. D., Holme, M. N., Ma, L., Rose, N. C., Nabarro, J., Fascione, M. A., Rashid, M. H., Yarovsky, I. & Stevens, M. M. Strain-Promoted Cycloadditions in Lipid Bilayers Triggered by Liposome Fusion. Angew. Chem. Int. Ed., 2024, 63 (14), e202314786

45

Walklett, A., Flack, E., Chidwick, H., Hatton, N., Keenan, T., Budhadev, D., Walton, J., Thomas, G. H., & Fascione, M. A. The Retaining Pse5Ac7Ac Pseudaminyltransferase KpsS1 Defines a Previously Unreported Glycosyltransferase Family (GT118). Angew. Chem. Int. Ed., 2024, 63 (15), e202318523

Highlighted as a Hot Article, and Martin highlighted in Angew Introducing...

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Tufail, A., Akkad, S., Hatton, N., Yates, N., Spears, R., Keenan, T., Parkin, A., Signoret, N. Y. M., & Fascione, M. A. Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal a-oxo aldehydes at acidic pH. RSC Adv., 2024,14, 3723-3729

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Keenan, T., Chidwick, H., Best, M., Flack, E., Yates, N., Hatton, N., Warnes, M. E., & Fascione, M. A. Co-factor prosthesis facilitates biosynthesis of azido-pseudaminic acid probes for use as glycosyltransferase reporters. Chem. Commun., 2024, 60, 1428-1431

42

Yates, N., Miles, C., Spicer, C., Fascione, M. A., & Parkin, A. Crossing the Solubility Rubicon: 15-Crown-5 Facilitates the Preparation of Water-Soluble Sulfo-NHS Esters in Organic Solvents. Bioconjug. Chem., 2024, 35 (1), 22-27

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Keenan, T., Hatton, N., Porter, J., Vendeville, J-B., Wheatley, D., Ghirardello, M., Ahmadipour , S., Walton, J., Galan, M. C., Linclau, B., & Miller, G. J., & Fascione, M. A. Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library. Chem. Sci., 2023,14, 11638-11646

Highlighted as inside Back Cover article

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Yates, N. D. J., Hatton, N. E., Fascione, M. A., & Parkin, A. Site-Selective Aryl Diazonium Installation onto Protein Surfaces at Neutral pH using a Maleimide-Functionalized Triazabutadiene. ChemBioChem, 2023, 24 (16), e202300313

39

Yates, N. D. J., Warnes, M. E., Breetveld, R., Spicer, C. D., Signoret, N., & Fascione, M. Preparation and Application of an Inexpensive α‐Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis. Org. Lett., 2023, 25 (12), 2001-2005

Highlighted as Front Cover article

38

Barber, L. J., Yates, N. D. J., Fascione, M. A., Parkin, A., Hemsworth, G. R., Genever, P. G., & Spicer, C. D. Selectivity and stability of N-terminal targeting protein modification chemistries. RSC Chem. Biol., 2023, 4, 56-64

37

Cioce , A., Calle, B., Rizou, T., Lowery, S., Bridgeman, V., Mahoney, K., Marchesi, A., Bineva-Todd, G., Flynn, H., Li, Z., Yilmaz Tastan, O., Roustan, C., Soro-Barrio, P., Rafiee, M-R., Garza-Garcia, A., Antonopoulos, A., Wood, T., Keenan, T., Both, P., Huang, K., Parmeggiani, F., Snijders, A. P., Skehel, M., Kjaer, S., Fascione, M. A., Bertozzi, C. R., Haslam, S. M., Flitsch, S., Malaker, S. A., Malanchi, I., & Schumann, B. Cell-specific bioorthogonal tagging of glycoproteins. Nat. Commun., 2022, 13, Article no. 6237

36

Yates, N., Akkad, S., Noble, A., Keenan, T., Hatton, N., Signoret, N. Y. M., & Fascione, M. A. Catalyst-free site-selective cross-aldol bioconjugations. Green Chem., 2022 , 24, 8046-8053

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Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N., & Fascione, M. A. A tale of two bioconjugations: pH controlled divergent reactivity of protein a-oxo aldehydes in competing a-oxo-Mannich and catalyst-free aldol ligations. ACS Chem. Biol., 2021, 16 (11), 2387-2400

Published as part of the ACS Young Investigators virtual special issue

34

Chidwick, H., Flack, E., Keenan, T., Walton, J., Thomas, G. H., & Fascione, M. A. Reconstitution and optimisation of the biosynthesis of bacterial sugar pseudaminic acid (Pse5Ac7Ac) enables preparative enzymatic synthesis of CMP-Pse5Ac7Ac. Sci. Rep., 2021, 11, Article no. 4756

33

Richards, S-J., Keenan, T., Vendeville, J-B., Wheatley, D. E., Chidwick, H., Budhadev, D., Council, C. E., Webster, C. S., Ledru, H., Baker, A. N., Walker, M., Galan, M. C., Linclau, B., Fascione, M. A., & Gibson, M. I. Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands. Chem. Sci., 2021,12, 905-910

32

Hatton, N., Baumann, C. G., & Fascione, M. A. Developments in mannose-based treatments for Uropathogenic Escherichia coli induced urinary tract infections. ChemBioChem, 2021, 22 (4), 613-629

31

Flack, E., Chidwick, H., Guchhait, G., Keenan, T., Budhadev, D., Huang, K., Both, P., Mas Pons, J., Ledru, H., Rui, S., Stafford, G., Shaw, J., Galan, M. C., Flitsch, S. L., Thomas, G. H., & Fascione, M. A. Biocatalytic Transfer of Pseudaminic Acid (Pse5Ac7Ac) Using Promiscuous Sialyltransferases in a Chemoenzymatic Approach to Pse5Ac7Ac Containing Glycosides. ACS Catal., 2020, 10 (17), 9986-9993

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Keenan, T., Parmeggiani, F., Malassis, J., Fontenelle, C., Vendeville, J-B., Offen, W. A., Both, P., Huang, K., Marchesi, A., Heyam, A. P., Young, C., Charnock, S. J., Davies, G. J., Linclau, B., Flitsch, S. L., & Fascione, M. A. Profiling substrate promiscuity of wild-type sugar kinases for multifluorinated monosaccharides. Cell Chem. Biol., 2020, 27 (9), 1199-1206

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Brabham, R., Keenan, T., Husken, A., Bilsborrow, J., McBerney, R., Kumar, V., Turnbull, W. B., & Fascione, M. A. Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation. Org. Biomol. Chem., 2020, 18, 4000-4003

Highlighted as a part of the themed collections: Editor's choice; Chemical Biology in OBC; Methodology development for protein modifications

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Valverde, P., Vendeville, J-B., Hollingsworth, K., Mattey, A. P., Keenan, T., Chidwick, H., Ledru, H., Huonnic, K., Light, M. E., Turner, N., Jimenez Barbero, J., Galan, M. C., Fascione, M. A., Flitsch, S., Turnbull, W. B., & Linclau, B. Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates. Chem. Commun., 2020, 56, 6408-6411

27

Flack, E., Chidwick, H., Best, M., Thomas, G. H., & Fascione, M. A. Synthetic Approaches for Accessing Pseudaminic Acid (Pse) Bacterial Glycans. ChemBioChem, 2020 , 21, 1-12.

26

Chidwick, H., & Fascione, M. A. Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac). Org. Biomol. Chem., 2020, 18, 799-809

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Yates, N., Dowsett, M., Bentley, P., Dickenson-Fogg, J., Pratt, A., Blanford, C., Fascione, M. A., & Parkin, A. Aldehyde-mediated protein-to-surface tethering via controlled diazonium electrode functionalization using protected hydroxylamines. Langmuir, 2020, 36 (20), 5654–5664

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Simpson, J. P., Fascione, M., Bergström, E., Wilson, J., Collins, M. J., Penkman, K. E. H., & Thomas-Oates, J. Ionisation bias undermines the use of matrix-assisted laser desorption/ionisation for estimating peptide deamidation: Synthetic peptide studies demonstrate electrospray ionisation gives more reliable response ratios. Rapid Commun. Mass Spectrom., 2019, 33 (12), 1049-1057

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Yates, N. D. J., Brabham, R. L., Spears, R. J., Keenan, T., Helliwell, P. A., Pugh, D. S., Parkin, A., Hurst, G. A., & Fascione, M. A. Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus. J. Chem. Educ., 2019, 96 (6), 1245-1249

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Keenan, T., Mills, R., Pocock, E., Budhadev, D., Parmeggiani, F., Flitsch, S. L., & Fascione, M. A. The characterisation of a galactokinase from Streptomyces coelicolor. Carbohydr. Res., 2019, 472, 132-137

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Budhadev, D., Saxby, K., Walton, J., Davies, G. J., Tyler, P., Schworer, R., & Fascione, M. A. Using Automated Glycan Assembly (AGA) for the Practical Synthesis of Heparan Sulfate Oligosaccharide Precursors. Org. Biomol. Chem., 2019, 7, 1817-1821

Highlighted as part of the themed collection: New Talent

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Spears, R. J., Brabham, R. L., Budhadev, D., Keenan, T., McKenna, S., Walton, J., Brannigan, J. A., Brzozowski, A. M., Wilkinson, A. J., Plevin, M. & Fascione, M. A. Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations. Chem. Sci., 2018, 9, 5585-5593

Highlighted as a HOT Article and in 2021 Nobel Prize in Chemistry Collection- Asymmetric Organocatalysis

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Yates, N. D. J., Fascione, M. A., & Parkin, A. Methodologies for “Wiring” Redox Proteins/Enzymes to Electrode Surfaces. Chem. Eur. J., 2018, 24, 1-20

18

Brabham, R. L., Spears, R. J., Walton, J., Tyagi, S., Lemke, E., & Fascione, M. A. Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification. Chem. Commun., 2018, 54, 1501-1504

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Budhadev, D., Schworer, R., & Fascione, M. A. Modern Methods for the Synthesis of Carbohydrates. In Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, 2018, pp. 234-269. The Royal Society of Chemistry.

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Mahon, C. S., J. McGurk, C., M. D. Watson, S., Fascione, M. A., Sakonsinsiri, C., Turnbull, W. B., & Fulton, D. A. Molecular-recognition mediated transformation of single-chain polymer nanoparticles into crosslinked polymer films. Angew. Chem. Int. Ed., 2017, 56 (42), 12913-12918

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Brabham, R. L., & Fascione, M. A. Pyrrolysine Amber Stop Codon Suppression: Development and Applications. ChemBioChem, 2017, 18 (20), 1937-1983

14

Brabham, R. L., & Fascione, M. A. Chiral auxiliaries in stereoselective glycosylation reactions. In C. Bennett (Ed.), Selective Glycosylations: Synthetic Methods and Catalysts, 2017, pp. 97-112. Wiley-Blackwell.

13

Spears, R. J., & Fascione, M. A. Site-selective incorporation and ligation of protein aldehydes. Org. Biomol. Chem., 2016, 14 (32), 7622-7638

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Guy, Y., Sakonsinsiri, C., Nehlmeier, I., Fascione, M. A., Zhang, H., Wang, W., Pohlmann, S., Turnbull, W. B., & Zhou, D. Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein–Ligand Interactions. Angew. Chem. Int. Ed., 2016, 55 (15), 4738-4742

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Fascione, M. A., Brabham, R., & Turnbull, W. B. Mechanistic Investigations into the Application of Sulfoxides in Carbohydrate Synthesis. Chem. Eur. J., 2016, 22 (12), 3916-3928

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Mahon, C. S., Fascione, M. A., Sakonsinsiri, C., McAllister, T. E., Turnbull, W. B., & Fulton, D. A. Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins. Org. Biomol. Chem., 2015, 13 (9), 2756-2761

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Branson, T. R., McAllister, T. E., Garcia-Hartjes, J., Fascione, M. A., Ross, J. F., Warriner, S. L., Wennekes, T., Zuilhof, H., & Turnbull, B. A protein-based pentavalent inhibitor of the Cholera toxin B-subunit. Angew. Chem. Int. Ed., 2014, 53 (32), 8323-8327

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Williamson, D. J., Fascione, M. A., Webb, M. E., & Turnbull, W. B. Efficient N-terminal labeling of proteins by use of sortase. Angew. Chem. Int. Ed., 2012, 51 (37), 9377-9380

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Fascione, M. A., Adshead, S. J., Mandal, P. K., Kilner, C. A., Leach, A. G., & Turnbull, W. B. Mechanistic studies on a sulfoxide transfer reaction mediated by diphenyl sulfoxide/triflic anhydride. Chem. Eur. J., 2012, 18 (10), 2987-2997

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Fascione, M. A., Webb, N. J., Kilner, C. A., Warriner, S. L., & Turnbull, W. B. Stereoselective glycosylations using oxathiane spiroketal glycosyl donors. Carbohydr. Res., 2012, 348, 6-13

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Fascione, M. A., Kilner, C. A., Leach, A. G., & Turnbull, W. B. Do glycosyl sulfonium ions engage in neighbouring-group participation? A Study of oxathiane glycosyl donors and the basis for their stereoselectivity. Chem. Eur. J., 2012, 18 (1), 321-333

4

Fascione, M. A., & Turnbull, W. B. Benzyne arylation of oxathiane glycosyl donors. Beilstein J. Org. Chem., 2010, 6, No. 19

3

Stalford, S. A., Fascione, M. A., Sasindran, S. J., Dhandayuthapani, S., Chatterjee, D. & Turnbull, W. B. A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A. Chem. Commun., 2009, 1, 110-112

2

Fascione, M. A., Adshead, S. J., Stalford, S. A., Kilner, C. A., Leach, A. G., & Turnbull, W. B. Stereoselective glycosylation using oxathiane glycosyl donors. Chem. Commun., 2009, 39, 5841-5843

1

Turnbull, W. B., Fascione, M. A., & Stalford, S. A. Product Class 14: glycosyl sulfur, selenium and tellurium compounds. In Science of Synthesis, 2007, Vol. 29, 923-969. Georg Thieme Verlag.

Patents

1

Fascione, M. A., Spears, R. J., Brabham, R., Budhadev, D., Keenan, T., Bioconjugation of polypeptides. W4 Apr 2019, IPC No. A61K 47/54, C07K 1/13, C07K 1/107, Patent No. WO/2019/063958, 27 Sept 2017

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